Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics

The missense variant, breast cancer resistance protein (BCRP) p.Q141K, which encodes a reduced function BCRP, has been linked to poor response to allopurinol. Using a multifaceted approach, we aimed to characterize the relationship(s) between BCRP p.Q141K, the pharmacokinetics (PK) and pharmacodynam...

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Detalles Bibliográficos
Autores principales: Vora, Bianca, Brackman, Deanna J., Zou, Ling, Garcia‐Cremades, Maria, Sirota, Marina, Savic, Radojka M., Giacomini, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301548/
https://www.ncbi.nlm.nih.gov/pubmed/33931953
http://dx.doi.org/10.1111/cts.12992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301548/
https://www.ncbi.nlm.nih.gov/pubmed/33931953
http://dx.doi.org/10.1111/cts.12992

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