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Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics

The missense variant, breast cancer resistance protein (BCRP) p.Q141K, which encodes a reduced function BCRP, has been linked to poor response to allopurinol. Using a multifaceted approach, we aimed to characterize the relationship(s) between BCRP p.Q141K, the pharmacokinetics (PK) and pharmacodynam...

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Detalles Bibliográficos
Autores principales:	Vora, Bianca, Brackman, Deanna J., Zou, Ling, Garcia‐Cremades, Maria, Sirota, Marina, Savic, Radojka M., Giacomini, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301548/ https://www.ncbi.nlm.nih.gov/pubmed/33931953 http://dx.doi.org/10.1111/cts.12992

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