Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers

RO6870868 is an oral prodrug of the toll‐like receptor 7 (TLR7) specific agonist, RO6871765. TLR7 agonists augment host immune activity and are in development to treat hepatitis B infection. We evaluated the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of RO6870868 in a f...

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Detalles Bibliográficos
Autores principales: Grippo, Joseph F., Folitar, Ilia, Passe, Sharon, Jiang, Qiudi, Rodriguez, Ignacio, Fettner, Scott H., Calleja, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301559/
https://www.ncbi.nlm.nih.gov/pubmed/33742764
http://dx.doi.org/10.1111/cts.13016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301559/
https://www.ncbi.nlm.nih.gov/pubmed/33742764
http://dx.doi.org/10.1111/cts.13016

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