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Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers
RO6870868 is an oral prodrug of the toll‐like receptor 7 (TLR7) specific agonist, RO6871765. TLR7 agonists augment host immune activity and are in development to treat hepatitis B infection. We evaluated the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of RO6870868 in a f...
Autores principales: | Grippo, Joseph F., Folitar, Ilia, Passe, Sharon, Jiang, Qiudi, Rodriguez, Ignacio, Fettner, Scott H., Calleja, Elizabeth |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301559/ https://www.ncbi.nlm.nih.gov/pubmed/33742764 http://dx.doi.org/10.1111/cts.13016 |
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