Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments

Over a decade of genome-wide association studies (GWAS) have led to the finding of extreme polygenicity of complex traits. The phenomenon that “all genes affect every complex trait” complicates Mendelian Randomization (MR) studies, where natural genetic variations are used as instruments to infer th...

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Detalles Bibliográficos
Autores principales: Wang, Jingshu, Zhao, Qingyuan, Bowden, Jack, Hemani, Gibran, Davey Smith, George, Small, Dylan S., Zhang, Nancy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301661/
https://www.ncbi.nlm.nih.gov/pubmed/34157017
http://dx.doi.org/10.1371/journal.pgen.1009575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301661/
https://www.ncbi.nlm.nih.gov/pubmed/34157017
http://dx.doi.org/10.1371/journal.pgen.1009575

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