New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-topoisomerase 1 (TOP1) stabilized by the TOP1 inhi...

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Detalles Bibliográficos
Autores principales: Dyrkheeva, Nadezhda S., Filimonov, Aleksandr S., Luzina, Olga A., Zakharenko, Alexandra L., Ilina, Ekaterina S., Malakhova, Anastasia A., Medvedev, Sergey P., Reynisson, Jóhannes, Volcho, Konstantin P., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301776/
https://www.ncbi.nlm.nih.gov/pubmed/34356597
http://dx.doi.org/10.3390/biom11070973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301776/
https://www.ncbi.nlm.nih.gov/pubmed/34356597
http://dx.doi.org/10.3390/biom11070973

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