Cargando…

Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia

Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of schizophrenia induced by systemic application of MK-8...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holubova, Kristina, Chvojkova, Marketa, Hrcka Krausova, Barbora, Vyklicky, Vojtech, Kudova, Eva, Chodounska, Hana, Vyklicky, Ladislav, Vales, Karel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301783/ https://www.ncbi.nlm.nih.gov/pubmed/34356650 http://dx.doi.org/10.3390/biom11071026

Ejemplares similares

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule
por: Vyklicky, Vojtech, et al.
Publicado: (2015)

Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif
por: Adla, Santosh Kumar, et al.
Publicado: (2018)

Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms
por: Smejkalova, Tereza, et al.
Publicado: (2021)

Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit
por: Vyklicky, Vojtech, et al.
Publicado: (2018)

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
por: Vyklicky, Vojtech, et al.
Publicado: (2021)

PM335. Neuroactive steroid treatment in the model of focal cerebra ischemia in immature brain
por: Vales, K., et al.
Publicado: (2016)

NMDA Receptor Opening and Closing—Transitions of a Molecular Machine Revealed by Molecular Dynamics
por: Černý, Jiří, et al.
Publicado: (2019)

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate
por: Ladislav, Marek, et al.
Publicado: (2018)

The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains
por: Kudova, Eva, et al.
Publicado: (2021)

Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors
por: Lichnerova, Katarina, et al.
Publicado: (2014)

Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
por: Szczurowska, Ewa, et al.
Publicado: (2022)

Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes
por: Kortus, Stepan, et al.
Publicado: (2023)

Modulation of NMDA Receptor Activity in Fibromyalgia
por: Littlejohn, Geoffrey, et al.
Publicado: (2017)

The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors
por: Skrenkova, Kristyna, et al.
Publicado: (2020)

Pregnanolone Glutamate, a Novel Use-Dependent NMDA Receptor Inhibitor, Exerts Antidepressant-Like Properties in Animal Models
por: Holubova, Kristina, et al.
Publicado: (2014)

NMDA Receptor Modulators in the Treatment of Drug Addiction
por: Tomek, Seven E., et al.
Publicado: (2013)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

Spider Neurotoxins as Modulators of NMDA Receptor Signaling
por: Pałasz, Artur, et al.
Publicado: (2021)

Promises and Pitfalls of NMDA Receptor Antagonists in Treating Violent Aggression
por: Bartsch, Caitlyn J., et al.
Publicado: (2022)

Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors
por: O'Neill, Nathanael, et al.
Publicado: (2018)

NMDA receptor modulation of glutamate release in activated neutrophils
por: del Arroyo, Ana Gutierrez, et al.
Publicado: (2019)

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems
por: Falsafi, Soheil Keihan, et al.
Publicado: (2012)

Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
por: Yao, Lulu, et al.
Publicado: (2017)

GPR40 modulates epileptic seizure and NMDA receptor function
por: Yang, Yong, et al.
Publicado: (2018)

NMDA receptor modulation and severe acute respiratory syndrome treatment
por: Costa, Blaise M.
Publicado: (2021)

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
por: Ritter, Nadine, et al.
Publicado: (2023)

Effects of Dizocilpine, Midazolam and Their Co-Application on the Trimethyltin (TMT)-Induced Rat Model of Cognitive Deficit
por: Chvojkova, Marketa, et al.
Publicado: (2021)

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies
por: Steinke, Stephan, et al.
Publicado: (2023)

Realising the therapeutic potential of neuroactive steroid modulators of the GABA(A) receptor
por: Belelli, Delia, et al.
Publicado: (2019)

Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies
por: Dean, Charles A., et al.
Publicado: (2022)

Stress-Induced Changes of Hippocampal NMDA Receptors: Modulation by Duloxetine Treatment
por: Calabrese, Francesca, et al.
Publicado: (2012)

Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
por: Black, Stefanie A. G., et al.
Publicado: (2014)

Interaction between NMDA Receptor- and Endocannabinoid-Mediated Modulation of Nociceptive Synapses
por: Yuan, Sharleen, et al.
Publicado: (2019)

Vestibular Modulation of Long-Term Potentiation and NMDA Receptor Expression in the Hippocampus
por: Smith, Paul F., et al.
Publicado: (2020)

Biased modulators of NMDA receptors control channel opening and ion selectivity
por: Perszyk, Riley E., et al.
Publicado: (2020)

Remembering Mechanosensitivity of NMDA Receptors
por: Johnson, Luke R., et al.
Publicado: (2019)

Tripartite signalling by NMDA receptors
por: Rajani, Vishaal, et al.
Publicado: (2020)

Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
por: Skrenkova, Kristyna, et al.
Publicado: (2019)

The NMDA Receptor Antibody Paradox: A Possible Approach to Developing Immunotherapies Targeting the NMDA Receptor
por: Young, Deborah
Publicado: (2020)

Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity
por: Li, Rui, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ucb3nkrv5hc8sva0fk8hgc8ls9