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The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex
Alzheimer’s disease is the most common progressive neurodegenerative disorder and is characterized by the presence of amyloid β (Aβ) plaques in the brain. The γ-secretase complex, which produces Aβ, is an intramembrane-cleaving protease consisting of four membrane proteins. In this paper we investig...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301813/ https://www.ncbi.nlm.nih.gov/pubmed/34202467 http://dx.doi.org/10.3390/biom11070935 |