Cytoplasmic Human TDP-43 Mislocalization Induces Widespread Dendritic Spine Loss in Mouse Upper Motor Neurons

Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lower motor neurons. Post-mortem, nearly all ALS cases are positive for cytoplasmic aggregates containing the DNA/RNA binding protein TDP-43. Recent studies indicate that this pathogenic mislocalization of TDP-43 may par...

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Detalles Bibliográficos
Autores principales: Dyer, Marcus S., Woodhouse, Adele, Blizzard, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301870/
https://www.ncbi.nlm.nih.gov/pubmed/34209287
http://dx.doi.org/10.3390/brainsci11070883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301870/
https://www.ncbi.nlm.nih.gov/pubmed/34209287
http://dx.doi.org/10.3390/brainsci11070883

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