Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells

The genetic principle of synthetic lethality has most successfully been exploited in therapies engaging Poly-ADP-ribose-polymerase (PARP) inhibitors to treat patients with homologous recombination (HR)-defective tumors. In this work, we went a step further following the idea of a local molecular coo...

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Detalles Bibliográficos
Autores principales: Malka, Matthews M., Eberle, Julia, Niedermayer, Kathrin, Zlotos, Darius P., Wiesmüller, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301877/
https://www.ncbi.nlm.nih.gov/pubmed/34356606
http://dx.doi.org/10.3390/biom11070981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301877/
https://www.ncbi.nlm.nih.gov/pubmed/34356606
http://dx.doi.org/10.3390/biom11070981

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