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α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?

Synucleinopathies are a heterogeneous group of neurodegenerative diseases with amyloid deposits that contain the α-synuclein (SNCA/α-Syn) protein as a common hallmark. It is astonishing that aggregates of a single protein are able to give rise to a whole range of different disease manifestations. Th...

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Detalles Bibliográficos
Autores principales: Hoppe, Simon Oliver, Uzunoğlu, Gamze, Nussbaum-Krammer, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301881/
https://www.ncbi.nlm.nih.gov/pubmed/34201558
http://dx.doi.org/10.3390/biom11070931