Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening

Allosteric modulators have emerged with many potential pharmacological advantages as they do not compete the binding of agonist or antagonist to the orthosteric sites but ultimately affect downstream signaling. To identify allosteric modulators targeting an extra-helical binding site of the glucagon...

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Detalles Bibliográficos
Autores principales: Zhou, Qingtong, Guo, Wanjing, Dai, Antao, Cai, Xiaoqing, Vass, Márton, de Graaf, Chris, Shui, Wenqing, Zhao, Suwen, Yang, Dehua, Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301998/
https://www.ncbi.nlm.nih.gov/pubmed/34201418
http://dx.doi.org/10.3390/biom11070929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301998/
https://www.ncbi.nlm.nih.gov/pubmed/34201418
http://dx.doi.org/10.3390/biom11070929

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