Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development

Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral load reduction, and evaluate the influence of intrinsic and...

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Detalles Bibliográficos
Autores principales: van den Berg, Paul, Gao, Wei, Ahsman, Maurice J., Arrington, Leticia, Kesisoglou, Filippos, Miller, Randy, Post, Teun M., Rizk, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302237/
https://www.ncbi.nlm.nih.gov/pubmed/33934558
http://dx.doi.org/10.1002/psp4.12644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302237/
https://www.ncbi.nlm.nih.gov/pubmed/33934558
http://dx.doi.org/10.1002/psp4.12644

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