An artificial neural network−pharmacokinetic model and its interpretation using Shapley additive explanations

We developed a method to apply artificial neural networks (ANNs) for predicting time‐series pharmacokinetics (PKs), and an interpretable the ANN‐PK model, which can explain the evidence of prediction by applying Shapley additive explanations (SHAP). A previous population PK (PopPK) model of cyclospo...

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Detalles Bibliográficos
Autores principales: Ogami, Chika, Tsuji, Yasuhiro, Seki, Hiroto, Kawano, Hideaki, To, Hideto, Matsumoto, Yoshiaki, Hosono, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302242/
https://www.ncbi.nlm.nih.gov/pubmed/33955705
http://dx.doi.org/10.1002/psp4.12643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302242/
https://www.ncbi.nlm.nih.gov/pubmed/33955705
http://dx.doi.org/10.1002/psp4.12643

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