A systems pharmacology model for gene therapy in sickle cell disease

We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene. These stem cells are expected to produce a lifelong supply of red blood cells (RBCs) containing an a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Bo, Wille, Lucia, Peppel, Karsten, Hagen, David, Matteson, Andrew, Ahlers, Jeffrey, Schaff, James, Hua, Fei, Yuraszeck, Theresa, Cobbina, Enoch, Apgar, Joshua F., Burke, John M., Roberts, John, Das, Raibatak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302248/
https://www.ncbi.nlm.nih.gov/pubmed/34139105
http://dx.doi.org/10.1002/psp4.12638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302248/
https://www.ncbi.nlm.nih.gov/pubmed/34139105
http://dx.doi.org/10.1002/psp4.12638

Ejemplares similares