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A systems pharmacology model for gene therapy in sickle cell disease

We developed a mathematical model for autologous stem cell therapy to cure sickle cell disease (SCD). Experimental therapies using this approach seek to engraft stem cells containing a curative gene. These stem cells are expected to produce a lifelong supply of red blood cells (RBCs) containing an a...

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Detalles Bibliográficos
Autores principales:	Zheng, Bo, Wille, Lucia, Peppel, Karsten, Hagen, David, Matteson, Andrew, Ahlers, Jeffrey, Schaff, James, Hua, Fei, Yuraszeck, Theresa, Cobbina, Enoch, Apgar, Joshua F., Burke, John M., Roberts, John, Das, Raibatak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302248/ https://www.ncbi.nlm.nih.gov/pubmed/34139105 http://dx.doi.org/10.1002/psp4.12638

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