Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker expression, and bacterial phenotype for each infected cell. This approach facilitates the dissection of the functiona...

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Detalles Bibliográficos
Autores principales: Pisu, Davide, Huang, Lu, Narang, Vipin, Theriault, Monique, Lê-Bury, Gabrielle, Lee, Bernett, Lakudzala, Agnes E., Mzinza, David T., Mhango, David V., Mitini-Nkhoma, Steven C., Jambo, Kondwani C., Singhal, Amit, Mwandumba, Henry C., Russell, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302446/
https://www.ncbi.nlm.nih.gov/pubmed/34292313
http://dx.doi.org/10.1084/jem.20210615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302446/
https://www.ncbi.nlm.nih.gov/pubmed/34292313
http://dx.doi.org/10.1084/jem.20210615

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