Presynaptic GABA(B) receptor–mediated network excitation in the medial prefrontal cortex of Tsc2(+/-) mice

The TSC1 and TSC2 tumor suppressor genes control the activity of mechanistic target of rapamycin (mTOR) pathway. Elevated activity of this pathway in Tsc2(+/-) mouse model leads to reduction of postsynaptic GABA(B) receptor–mediated inhibition and hyperexcitability in the medial prefrontal cortex (m...

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Detalles Bibliográficos
Autores principales: Bassetti, Davide, Luhmann, Heiko J., Kirischuk, Sergei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Molecular and Cellular Mechanisms of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302497/
https://www.ncbi.nlm.nih.gov/pubmed/34279736
http://dx.doi.org/10.1007/s00424-021-02576-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302497/
https://www.ncbi.nlm.nih.gov/pubmed/34279736
http://dx.doi.org/10.1007/s00424-021-02576-5

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