Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome

Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic drugs (AEDs). In 2020, FDA has approved fenfluramine (FFA) for treatment of seizures associated with DS. However, the clinically used FFA is a racemic mi...

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Detalles Bibliográficos
Autores principales: Li, Jing, Nelis, Maxim, Sourbron, Jo, Copmans, Daniëlle, Lagae, Lieven, Cabooter, Deirdre, de Witte, Peter A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302504/
https://www.ncbi.nlm.nih.gov/pubmed/34041623
http://dx.doi.org/10.1007/s11064-021-03358-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302504/
https://www.ncbi.nlm.nih.gov/pubmed/34041623
http://dx.doi.org/10.1007/s11064-021-03358-2

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