Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection has emerged as a route for cancer therapy. Splicing modulators alter the splicing patterns in cells by binding to the U2 snRNP (small nuclear ribonucleoprotein)—...

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Detalles Bibliográficos
Autores principales: Cretu, Constantin, Gee, Patricia, Liu, Xiang, Agrawal, Anant, Nguyen, Tuong-Vi, Ghosh, Arun K., Cook, Andrew, Jurica, Melissa, Larsen, Nicholas A., Pena, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302644/
https://www.ncbi.nlm.nih.gov/pubmed/34301950
http://dx.doi.org/10.1038/s41467-021-24741-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302644/
https://www.ncbi.nlm.nih.gov/pubmed/34301950
http://dx.doi.org/10.1038/s41467-021-24741-1

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