Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate excretion. I...

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Detalles Bibliográficos
Autores principales: Ogura, Yurie, Kaneko, Ryoji, Ujibe, Kota, Wakamatsu, Yuma, Hirata, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302672/
https://www.ncbi.nlm.nih.gov/pubmed/34301962
http://dx.doi.org/10.1038/s41598-021-93909-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302672/
https://www.ncbi.nlm.nih.gov/pubmed/34301962
http://dx.doi.org/10.1038/s41598-021-93909-y

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