Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, how to model the effect of APOE, what the optim...

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Detalles Bibliográficos
Autores principales: Leonenko, Ganna, Baker, Emily, Stevenson-Hoare, Joshua, Sierksma, Annerieke, Fiers, Mark, Williams, Julie, de Strooper, Bart, Escott-Price, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302739/
https://www.ncbi.nlm.nih.gov/pubmed/34301930
http://dx.doi.org/10.1038/s41467-021-24082-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302739/
https://www.ncbi.nlm.nih.gov/pubmed/34301930
http://dx.doi.org/10.1038/s41467-021-24082-z

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