Cargando…

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, how to model the effect of APOE, what the optim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leonenko, Ganna, Baker, Emily, Stevenson-Hoare, Joshua, Sierksma, Annerieke, Fiers, Mark, Williams, Julie, de Strooper, Bart, Escott-Price, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302739/ https://www.ncbi.nlm.nih.gov/pubmed/34301930 http://dx.doi.org/10.1038/s41467-021-24082-z

Ejemplares similares

Polygenic risk and hazard scores for Alzheimer's disease prediction
por: Leonenko, Ganna, et al.
Publicado: (2019)

Age-dependent effect of APOE and polygenic component on Alzheimer's disease
por: Bellou, Eftychia, et al.
Publicado: (2020)

Polygenic Risk Scores in Alzheimer's Disease: Current Applications and Future Directions
por: Baker, Emily, et al.
Publicado: (2020)

Polygenic risk and pleiotropy in neurodegenerative diseases
por: Bellou, Eftychia, et al.
Publicado: (2020)

Comparison of long-term effects of metformin on longevity between people with type 2 diabetes and matched non-diabetic controls
por: Stevenson-Hoare, Joshua, et al.
Publicado: (2023)

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer’s disease through polygenic risk and RNA sequencing
por: Crawford, Karen, et al.
Publicado: (2022)

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease
por: Stevenson-Hoare, Joshua, et al.
Publicado: (2022)

Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition
por: Leonenko, Ganna, et al.
Publicado: (2019)

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
por: Sierksma, Annerieke, et al.
Publicado: (2020)

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
por: Salta, Evgenia, et al.
Publicado: (2016)

POLARIS: Polygenic LD‐adjusted risk score approach for set‐based analysis of GWAS data
por: Baker, Emily, et al.
Publicado: (2018)

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins
por: Karlsson, Ida K., et al.
Publicado: (2022)

Defining functional variants associated with Alzheimer’s disease in the induced immune response
por: Harwood, Janet C, et al.
Publicado: (2021)

From Polygenic Scores to Precision Medicine in Alzheimer’s Disease: A Systematic Review
por: Harrison, Judith R., et al.
Publicado: (2020)

Polygenic Risk Score Analysis of Alzheimer’s Disease in Cases without APOE4 or APOE2 Alleles
por: Escott-Price, V., et al.
Publicado: (2018)

From Junk to Function: LncRNAs in CNS Health and Disease
por: Policarpo, Rafaela, et al.
Publicado: (2021)

Polygenic resilience scores capture protective genetic effects for Alzheimer’s disease
por: Hou, Jiahui, et al.
Publicado: (2022)

Pathway-specific polygenic scores for Alzheimer’s disease are associated with changes in brain structure in younger and older adults
por: Harrison, Judith R, et al.
Publicado: (2023)

Machine learning for the life-time risk prediction of Alzheimer’s disease: a systematic review
por: Rowe, Thomas W, et al.
Publicado: (2021)

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
por: Sierksma, Annerieke, et al.
Publicado: (2018)

Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis
por: Bracher-Smith, Matthew, et al.
Publicado: (2022)

Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach
por: Vivian‐Griffiths, Timothy, et al.
Publicado: (2018)

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
por: de Rojas, Itziar, et al.
Publicado: (2021)

GenoRisk: A polygenic risk score for Alzheimer's disease
por: Dickson, Samuel P., et al.
Publicado: (2021)

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
por: Balusu, Sriram, et al.
Publicado: (2023)

Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease
por: Qiao, Min, et al.
Publicado: (2023)

Polygenic risk of Parkinson disease is correlated with disease age at onset
por: Escott‐Price, Valentina, et al.
Publicado: (2015)

Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
por: de Rojas, Itziar, et al.
Publicado: (2023)

The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia
por: Richards, Alexander L, et al.
Publicado: (2020)

Polygenic risk score for Alzheimer’s disease and trajectories of cardiometabolic risk factors in children
por: Korologou-Linden, Roxanna, et al.
Publicado: (2019)

Association Between Polygenic Risk Score and Risk of Myopia
por: Ghorbani Mojarrad, Neema, et al.
Publicado: (2019)

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population
por: Zhou, Xiaopu, et al.
Publicado: (2020)

Associations of Polygenic Risk Score for Late-Onset Alzheimer's Disease With Biomarkers
por: Li, Qiaojun, et al.
Publicado: (2022)

Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer’s Disease
por: Vlachakis, Dimitrios, et al.
Publicado: (2021)

Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
por: Veteleanu, Aurora, et al.
Publicado: (2023)

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
por: Liang, Yanyu, et al.
Publicado: (2022)

Polygenic Risk Scores in Alzheimer’s Disease Genetics: Methodology, Applications, Inclusion, and Diversity
por: Clark, Kaylyn, et al.
Publicado: (2022)

Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives
por: Najar, Jenna, et al.
Publicado: (2021)

Phenotype‐informed polygenic risk scores are associated with worse outcome in individuals at risk of Alzheimer's disease
por: Nordengen, Kaja, et al.
Publicado: (2022)

Epistatic Features and Machine Learning Improve Alzheimer’s Risk Prediction Over Polygenic Risk Scores
por: Hermes, Stephen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_661fvt4q27r64ti2iqb8s63rab