FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes

The transcription factor SOX2 is important for brain development and for neural stem cells (NSC) maintenance. Sox2-deleted (Sox2-del) NSC from neonatal mouse brain are lost after few passages in culture. Two highly expressed genes, Fos and Socs3, are strongly downregulated in Sox2-del NSC; we previo...

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Detalles Bibliográficos
Autores principales: Pagin, Miriam, Pernebrink, Mattias, Pitasi, Mattia, Malighetti, Federica, Ngan, Chew-Yee, Ottolenghi, Sergio, Pavesi, Giulio, Cantù, Claudio, Nicolis, Silvia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303191/
https://www.ncbi.nlm.nih.gov/pubmed/34359927
http://dx.doi.org/10.3390/cells10071757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303191/
https://www.ncbi.nlm.nih.gov/pubmed/34359927
http://dx.doi.org/10.3390/cells10071757

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