TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks

SIMPLE SUMMARY: Here, we reveal that basal turnover and autophagy-induced decay of the ubiquitin E3 ligase TRAF6 is antagonized by IKKε-mediated phosphorylation at five serines. Phosphoproteomic experiments show that TRAF6 and its phosphorylation contribute to the remodeling of LPS- and autophagyind...

Descripción completa

Detalles Bibliográficos
Autores principales: Busch, Julia, Moreno, Rita, de la Vega, Laureano, Saul, Vera Vivian, Bacher, Susanne, von Zweydorf, Felix, Ueffing, Marius, Weber, Axel, Gloeckner, Christian Johannes, Linne, Uwe, Kracht, Michael, Schmitz, Michael Lienhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303406/
https://www.ncbi.nlm.nih.gov/pubmed/34298830
http://dx.doi.org/10.3390/cancers13143618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303406/
https://www.ncbi.nlm.nih.gov/pubmed/34298830
http://dx.doi.org/10.3390/cancers13143618

Ejemplares similares