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TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks

SIMPLE SUMMARY: Here, we reveal that basal turnover and autophagy-induced decay of the ubiquitin E3 ligase TRAF6 is antagonized by IKKε-mediated phosphorylation at five serines. Phosphoproteomic experiments show that TRAF6 and its phosphorylation contribute to the remodeling of LPS- and autophagyind...

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Detalles Bibliográficos
Autores principales:	Busch, Julia, Moreno, Rita, de la Vega, Laureano, Saul, Vera Vivian, Bacher, Susanne, von Zweydorf, Felix, Ueffing, Marius, Weber, Axel, Gloeckner, Christian Johannes, Linne, Uwe, Kracht, Michael, Schmitz, Michael Lienhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303406/ https://www.ncbi.nlm.nih.gov/pubmed/34298830 http://dx.doi.org/10.3390/cancers13143618

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