Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity

Background: The proximal tubule (PT) is the major target of cadmium (Cd(2+)) nephrotoxicity. Current dogma postulates that Cd(2+) complexed to metallothionein (MT) (CdMT) is taken up through receptor-mediated endocytosis (RME) via the PT receptor megalin:cubilin, which is the predominant pathway for...

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Detalles Bibliográficos
Autores principales: Zavala-Guevara, Itzel Pamela, Ortega-Romero, Manolo Sibael, Narváez-Morales, Juana, Jacobo-Estrada, Tania Libertad, Lee, Wing-Kee, Arreola-Mendoza, Laura, Thévenod, Frank, Barbier, Olivier Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303618/
https://www.ncbi.nlm.nih.gov/pubmed/34298880
http://dx.doi.org/10.3390/ijms22147262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303618/
https://www.ncbi.nlm.nih.gov/pubmed/34298880
http://dx.doi.org/10.3390/ijms22147262

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