The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons

The compounds 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (2) and 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin (3) are potential topoisomerase I poisons. Moreover, they were shown to have favorable anti-neoplastic effects on several tumor cell lines. Due to these properties, the...

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Detalles Bibliográficos
Autores principales: Bocian, Wojciech, Naumczuk, Beata, Urbanowicz, Magdalena, Sitkowski, Jerzy, Bierczyńska-Krzysik, Anna, Bednarek, Elżbieta, Wiktorska, Katarzyna, Milczarek, Małgorzata, Kozerski, Lech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303725/
https://www.ncbi.nlm.nih.gov/pubmed/34299090
http://dx.doi.org/10.3390/ijms22147471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303725/
https://www.ncbi.nlm.nih.gov/pubmed/34299090
http://dx.doi.org/10.3390/ijms22147471

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