Single-Cell Transcriptome Profiling Simulation Reveals the Impact of Sequencing Parameters and Algorithms on Clustering

Despite the scRNA-seq analytic algorithms developed, their performance for cell clustering cannot be quantified due to the unknown “true” clusters. Referencing the transcriptomic heterogeneity of cell clusters, a “true” mRNA number matrix of cell individuals was defined as ground truth. Based on the...

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Detalles Bibliográficos
Autores principales: Liu, Yunhe, Wu, Aoshen, Peng, Xueqing, Liu, Xiaona, Liu, Gang, Liu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304014/
https://www.ncbi.nlm.nih.gov/pubmed/34357088
http://dx.doi.org/10.3390/life11070716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304014/
https://www.ncbi.nlm.nih.gov/pubmed/34357088
http://dx.doi.org/10.3390/life11070716

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