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Double Proton Tautomerism via Intra- or Intermolecular Pathways? The Case of Tetramethyl Reductic Acid Studied by Dynamic NMR: Hydrogen Bond Association, Solvent and Kinetic H/D Isotope Effects

Using dynamic liquid-state NMR spectroscopy a degenerate double proton tautomerism was detected in tetramethyl reductic acid (TMRA) dissolved in toluene-d(8) and in CD(2)Cl(2). Similar to vitamin C, TMRA belongs to the class of reductones of biologically important compounds. The tautomerism involves...

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Detalles Bibliográficos
Autores principales:	Limbach, Hans-Heinrich, Baumgärtner, Simone, Franke, Roland, Männle, Ferdinand, Scherer, Gerd, Denisov, Gleb S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304075/ https://www.ncbi.nlm.nih.gov/pubmed/34299648 http://dx.doi.org/10.3390/molecules26144373

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