Cargando…

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 is essential for the postnatal maturation of the cochlea and the correct wiring of hearing in mice. Less severe decreases in human IGF-1 levels have been associated with other h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Celaya, Adelaida M., Rodríguez-de la Rosa, Lourdes, Bermúdez-Muñoz, Jose M., Zubeldia, José M., Romá-Mateo, Carlos, Avendaño, Carlos, Pallardó, Federico V., Varela-Nieto, Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304185/ https://www.ncbi.nlm.nih.gov/pubmed/34359856 http://dx.doi.org/10.3390/cells10071686

Ejemplares similares

G6PD overexpression protects from oxidative stress and age‐related hearing loss
por: Bermúdez‐Muñoz, Jose M., et al.
Publicado: (2020)

Transforming growth factor β1 inhibition protects from noise-induced hearing loss
por: Murillo-Cuesta, Silvia, et al.
Publicado: (2015)

Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss
por: Murillo-Cuesta, Silvia, et al.
Publicado: (2015)

Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss
por: Murillo‐Cuesta, Silvia, et al.
Publicado: (2021)

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
por: Celaya, Adelaida M, et al.
Publicado: (2019)

Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1(−/−) Mouse
por: Fuentes-Santamaría, Veronica, et al.
Publicado: (2019)

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea
por: Bermúdez-Muñoz, Jose M., et al.
Publicado: (2021)

Swept-sine noise-induced damage as a hearing loss model for preclinical assays
por: Sanz, Lorena, et al.
Publicado: (2015)

Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays
por: Sanz, Lorena, et al.
Publicado: (2015)

Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
por: Shi, Lijuan, et al.
Publicado: (2016)

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss
por: Partearroyo, Teresa, et al.
Publicado: (2017)

Cochlear Proteins Associated with Noise-induced Hearing Loss: An Update
por: Jain, Ruchika K., et al.
Publicado: (2018)

A Comparative Study of Age-Related Hearing Loss in Wild Type and Insulin-Like Growth Factor I Deficient Mice
por: Riquelme, Raquel, et al.
Publicado: (2010)

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders
por: Muñoz-Lasso, Diana C., et al.
Publicado: (2020)

Error Patterns Analysis of Hearing Aid and Cochlear Implant Users as a Function of Noise
por: Chun, Hyungi, et al.
Publicado: (2015)

Constant Light Dysregulates Cochlear Circadian Clock and Exacerbates Noise-Induced Hearing Loss
por: Yang, Chao-Hui, et al.
Publicado: (2020)

Hearing Preservation in Cochlear Implant Surgery
por: Miranda, Priscila Carvalho, et al.
Publicado: (2014)

Antioxidants and Vasodilators for the Treatment of Noise-Induced Hearing Loss: Are They Really Effective?
por: Alvarado, Juan Carlos, et al.
Publicado: (2020)

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss
por: Kalinec, Gilda M., et al.
Publicado: (2017)

C-Raf deficiency leads to hearing loss and increased noise susceptibility
por: de Iriarte Rodríguez, Rocío, et al.
Publicado: (2015)

The Influence of Cochlear Mechanical Dysfunction, Temporal Processing Deficits, and Age on the Intelligibility of Audible Speech in Noise for Hearing-Impaired Listeners
por: Johannesen, Peter T., et al.
Publicado: (2016)

Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity
por: Lai, Jesyin, et al.
Publicado: (2022)

Spatial hearing of normally hearing and cochlear implanted children
por: Murphy, John, et al.
Publicado: (2011)

Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss
por: Miao, Long, et al.
Publicado: (2022)

Thioredoxin and Glutaredoxin Systems as Potential Targets for the Development of New Treatments in Friedreich’s Ataxia
por: Seco-Cervera, Marta, et al.
Publicado: (2020)

Ultrastructure of noise-induced cochlear synaptopathy
por: Moverman, Daniel J., et al.
Publicado: (2023)

The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss
por: Fetoni, A. R., et al.
Publicado: (2016)

Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
por: Corns, Laura F., et al.
Publicado: (2016)

Improved hearing in noise using new signal processing algorithms with the Cochlear™ Nucleus(®) 6 sound processor
por: Gilden, Jan, et al.
Publicado: (2015)

Hidden Hearing Loss? No Effect of Common Recreational Noise Exposure on Cochlear Nerve Response Amplitude in Humans
por: Grinn, Sarah K., et al.
Publicado: (2017)

Auditory stream segregation of amplitude-modulated narrowband noise in cochlear implant users and individuals with normal hearing
por: Matz, Alexandria F., et al.
Publicado: (2022)

Music in noise recognition: An EEG study of listening effort in cochlear implant users and normal hearing controls
por: Cartocci, Giulia, et al.
Publicado: (2023)

Acceptable noise level as a deciding factor for prescribing hearing aids for older adults with cochlear hearing loss – A scoping review
por: Shetty, Hemanth Narayan, et al.
Publicado: (2015)

Is All Human Hearing Cochlear?
por: Emami, Seyede Faranak
Publicado: (2013)

Listening efficiency in adult cochlear-implant users compared with normally-hearing controls at ecologically relevant signal-to-noise ratios
por: Perea Pérez, Francisca, et al.
Publicado: (2023)

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
por: Murillo-Cuesta, Silvia, et al.
Publicado: (2017)

SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans
por: Guan, Jing, et al.
Publicado: (2016)

Acute Recreational Noise-Induced Cochlear Synaptic Dysfunction in Humans With Normal Hearing: A Prospective Cohort Study
por: Wang, Qixuan, et al.
Publicado: (2021)

Changes in microRNA Expression in the Cochlear Nucleus and Inferior Colliculus after Acute Noise-Induced Hearing Loss
por: Park, Sohyeon, et al.
Publicado: (2020)

TMT-Based Quantitative Proteomics Reveals Cochlear Protein Profile Alterations in Mice with Noise-Induced Hearing Loss
por: Miao, Long, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3a4r4tcq8fl6u03ce453cvg6c8