Expression of RUNX1-JAK2 in Human Induced Pluripotent Stem Cell-Derived Hematopoietic Cells Activates the JAK-STAT and MYC Pathways

A heterogeneous genetic subtype of B-cell precursor acute lymphoblastic leukemia is driven by constitutive kinase-activation, including patients with JAK2 fusions. In our study, we model the impact of a novel JAK2 fusion protein on hematopoietic development in human induced pluripotent stem cells (h...

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Detalles Bibliográficos
Autores principales: Fortschegger, Klaus, Husa, Anna-Maria, Schinnerl, Dagmar, Nebral, Karin, Strehl, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304339/
https://www.ncbi.nlm.nih.gov/pubmed/34299194
http://dx.doi.org/10.3390/ijms22147576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304339/
https://www.ncbi.nlm.nih.gov/pubmed/34299194
http://dx.doi.org/10.3390/ijms22147576

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