IL-15 Enhances the Persistence and Function of BCMA-Targeting CAR-T Cells Compared to IL-2 or IL-15/IL-7 by Limiting CAR-T Cell Dysfunction and Differentiation

SIMPLE SUMMARY: T cells modified with a chimeric antigen receptor (CAR) that targets BCMA, a protein expressed on malignant plasma cells, represent a novel treatment option for multiple myeloma. Despite initially eliminating the disease, the function of BCMA-directed CAR-T cells diminishes within a...

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Detalles Bibliográficos
Autores principales: Battram, Anthony M., Bachiller, Mireia, Lopez, Victor, Fernández de Larrea, Carlos, Urbano-Ispizua, Alvaro, Martín-Antonio, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304527/
https://www.ncbi.nlm.nih.gov/pubmed/34298748
http://dx.doi.org/10.3390/cancers13143534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304527/
https://www.ncbi.nlm.nih.gov/pubmed/34298748
http://dx.doi.org/10.3390/cancers13143534

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