Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary tangles is a hallmark of Alzheimer’s disease (AD). Tau pathology correlates not only with progressive dementia but also with microglia-mediated inflammation in AD. Amyloid-beta (Aβ), another pathogenic peptide i...

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Detalles Bibliográficos
Autores principales: Panda, Chinmaya, Voelz, Clara, Habib, Pardes, Mevissen, Christian, Pufe, Thomas, Beyer, Cordian, Gupta, Sharad, Slowik, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304967/
https://www.ncbi.nlm.nih.gov/pubmed/34209408
http://dx.doi.org/10.3390/cells10071652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304967/
https://www.ncbi.nlm.nih.gov/pubmed/34209408
http://dx.doi.org/10.3390/cells10071652

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