Cargando…

Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action

Pentathiepins are polysulfur-containing compounds that exert antiproliferative and cytotoxic activity in cancer cells, induce oxidative stress and apoptosis, and inhibit glutathione peroxidase (GPx1). This renders them promising candidates for anticancer drug development. However, the biological eff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wolff, Lisa, Bandaru, Siva Sankar Murthy, Eger, Elias, Lam, Hoai-Nhi, Napierkowski, Martin, Baecker, Daniel, Schulzke, Carola, Bednarski, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305076/ https://www.ncbi.nlm.nih.gov/pubmed/34299253 http://dx.doi.org/10.3390/ijms22147631

Ejemplares similares

Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells
por: Behnisch‐Cornwell, Steven, et al.
Publicado: (2020)

Crystal structure of 4-(pyrazin-2-yl)morpholine
por: Bandaru, Siva Sankar Murthy, et al.
Publicado: (2018)

Synthesis and Identification of Pentathiepin-Based Inhibitors of Sporothrix brasiliensis
por: Asquith, Christopher R. M., et al.
Publicado: (2019)

Synthesis of 9-arylalkynyl- and 9-aryl-substituted benzo[b]quinolizinium derivatives by Palladium-mediated cross-coupling reactions
por: Bandaru, Siva Sankar Murthy, et al.
Publicado: (2018)

The Mechanism of Metal-Containing Formate Dehydrogenases Revisited: The Formation of Bicarbonate as Product Intermediate Provides Evidence for an Oxygen Atom Transfer Mechanism
por: Kumar, Hemant, et al.
Publicado: (2023)

Comprehensive review of SGLT2 inhibitors’ efficacy through their diuretic mode of action in diabetic patients
por: Lam-Chung, Cesar Ernesto
Publicado: (2023)

Various modes of action of dietary phytochemicals, sulforaphane and phenethyl isothiocyanate, on pathogenic bacteria
por: Nowicki, Dariusz, et al.
Publicado: (2019)

Sensitivity differences among seven algal species to 12 herbicides with various modes of action
por: Nagai, Takashi
Publicado: (2019)

Ecological effect assessment by species sensitivity distribution for 38 pesticides with various modes of action
por: Nagai, Takashi
Publicado: (2021)

Crystal structure of 1-ethyl-3-(2-oxo-1,3-dithiol-4-yl)quinoxalin-2(1H)-one
por: Chrysochos, Nicolas, et al.
Publicado: (2018)

Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review
por: Ghaseminejad-Raeini, Amirhossein, et al.
Publicado: (2023)

Action of Various Diuretics
Publicado: (1880)

On the Various Modes of Treating Intermittents in Paris
Publicado: (1830)

Various Modes Adopted in Filling Teeth
por: Sachs, Wilhelm
Publicado: (1890)

Which functional groups of the molybdopterin ligand should be considered when modeling the active sites of the molybdenum and tungsten cofactors? A density functional theory study
por: Ryde, Ulf, et al.
Publicado: (2009)

Crystal structures of 4,4′-(disulfane-1,2-diyl)bis(5-methyl-2H-1,3-dithiol-2-one) and 4,4′-(diselanane-1,2-diyl)bis(5-methyl-2H-1,3-dithiol-2-one)
por: Trentin, Ivan, et al.
Publicado: (2018)

On the Mode of Action of Strychnia
Publicado: (1868)

On the Mode of Action of Strychnia
por: Spence, Alexander Ingram
Publicado: (1866)

A Comprehensive Review of the Current Knowledge of Chlorfenapyr: Synthesis, Mode of Action, Resistance, and Environmental Toxicology
por: Huang, Ping, et al.
Publicado: (2023)

Sensitivity differences among five species of aquatic fungi and fungus-like organisms for seven fungicides with various modes of action
por: Nagai, Takashi
Publicado: (2020)

Molecular structure of fac-[Mo(CO)(3)(DMSO)(3)]
por: Elvers, Benedict J., et al.
Publicado: (2021)

Retinoid metabolism and mode of action.
por: De Luca, L M, et al.
Publicado: (1980)

Vaccine Adjuvants: Mode of Action
por: De Gregorio, Ennio, et al.
Publicado: (2013)

On the Structure and Mode of Action of the Iris
por: Hall, C. R.
Publicado: (1844)

The mode of action of anticholinergics in asthma
por: Gosens, Reinoud, et al.
Publicado: (2018)

The Discovery of the Mode of Action of Nitisinone
por: Lock, Edward A.
Publicado: (2022)

COVID-19 diagnosis: A comprehensive review of pre-trained deep learning models based on feature extraction algorithm
por: Poola, Rahul Gowtham, et al.
Publicado: (2023)

Correlation Analysis of Protein Expression of 10 HDAC/Sirtuin Isoenzymes with Sensitivities of 23 Anticancer Drugs in 17 Cancer Cell Lines and Potentiation of Drug Activity by Co-Treatment with HDAC Inhibitors
por: Behnisch-Cornwell, Steven, et al.
Publicado: (2021)

Indoor Finish Material Influence on Contamination, Transmission, and Eradication of Methicillin-Resistant Staphylococcus aureus (MRSA)
por: Harris, Debra, et al.
Publicado: (2020)

Crystal structure of the triethylammonium salt of 3-[(4-hydroxy-3-methoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2-oxo-2H-chromen-4-olate
por: Ikram, Muhammad, et al.
Publicado: (2018)

Comprehensive radation doses for various villages.
por: Serge Dailler
Publicado: (1997)

Apparent Want of Action in Various Arteries
por: Lara,, et al.
Publicado: (1817)

Standard Filling Schemes for Various LHC Operation Modes
por: Bailey, R, et al.
Publicado: (2003)

Modes of Action of a Bi-domain Plant Defensin MtDef5 Against a Bacterial Pathogen Xanthomonas campestris
por: Velivelli, Siva L. S., et al.
Publicado: (2018)

Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine
por: Gayakhe, Vijay, et al.
Publicado: (2017)

An Asymmetrically Substituted Aliphatic Bis-Dithiolene Mono-Oxido Molybdenum(IV) Complex With Ester and Alcohol Functions as Structural and Functional Active Site Model of Molybdoenzymes
por: Ahmadi, Mohsen, et al.
Publicado: (2019)

A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility
por: Elias, Rita, et al.
Publicado: (2021)

Modes of action of trichloroethylene for kidney tumorigenesis.
por: Lash, L H, et al.
Publicado: (2000)

STUDIES ON THE MODE OF ACTION OF LATHYROGENIC COMPOUNDS
por: Levene, C. I.
Publicado: (1962)

THE MODE OF ACTION OF SULFANILAMIDE ON STREPTOCOCCUS. II
por: Gay, Frederick P., et al.
Publicado: (1939)

Cannot write session to /tmp/vufind_sessions/sess_f34a426k89ho1pbipk8iq8r8ue