The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model

The hexosamine biosynthetic pathway (HBP) is essential for the production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the building block of glycosaminoglycans, thus playing a crucial role in cartilage anabolism. Although O-GlcNAcylation represents a protective regulatory mechanism in ce...

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Detalles Bibliográficos
Autores principales: Riegger, Jana, Baumert, Julia, Zaucke, Frank, Brenner, Rolf E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305151/
https://www.ncbi.nlm.nih.gov/pubmed/34298867
http://dx.doi.org/10.3390/ijms22147247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305151/
https://www.ncbi.nlm.nih.gov/pubmed/34298867
http://dx.doi.org/10.3390/ijms22147247

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