Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg(2+) or Mn(2+) ions located in the enzyme’s catalytic site. Pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Reiberger, Robert, Radilová, Kateřina, Kráľ, Michal, Zima, Václav, Majer, Pavel, Brynda, Jiří, Dračínský, Martin, Konvalinka, Jan, Kožíšek, Milan, Machara, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305651/
https://www.ncbi.nlm.nih.gov/pubmed/34299354
http://dx.doi.org/10.3390/ijms22147735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305651/
https://www.ncbi.nlm.nih.gov/pubmed/34299354
http://dx.doi.org/10.3390/ijms22147735

Ejemplares similares