In Silico Prediction, Molecular Docking and Dynamics Studies of Steroidal Alkaloids of Holarrhena pubescens Wall. ex G. Don to Guanylyl Cyclase C: Implications in Designing of Novel Antidiarrheal Therapeutic Strategies

The binding of heat stable enterotoxin (STa) secreted by enterotoxigenic Escherichia coli (ETEC) to the extracellular domain of guanylyl cyclase c (ECD(GC-C)) causes activation of a signaling cascade, which ultimately results in watery diarrhea. We carried out this study with the objective of findin...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Neha, Choudhary, Saurav Kumar, Bhagat, Neeta, Karthikeyan, Muthusamy, Chaturvedi, Archana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305770/
https://www.ncbi.nlm.nih.gov/pubmed/34299422
http://dx.doi.org/10.3390/molecules26144147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305770/
https://www.ncbi.nlm.nih.gov/pubmed/34299422
http://dx.doi.org/10.3390/molecules26144147

Ejemplares similares