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Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition

Protecting telomere from the DNA damage response is essential to avoid the entry into cellular senescence and organismal aging. The progressive telomere DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger replicative senescence an...

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Detalles Bibliográficos
Autores principales: Ghilain, Claire, Gilson, Eric, Giraud-Panis, Marie-Josèphe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305809/
https://www.ncbi.nlm.nih.gov/pubmed/34359923
http://dx.doi.org/10.3390/cells10071753