New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling

SIMPLE SUMMARY: The purpose of this study was to analyze differential cell signaling in response to denosumab treatment to identify and subsequently inhibit molecular targets in the neoplastic stromal cell population, which poses a risk for tumor recurrence. Using phosphoprotein arrays, a distinct s...

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Detalles Bibliográficos
Autores principales: Mahdal, Michal, Neradil, Jakub, Mudry, Peter, Paukovcekova, Silvia, Staniczkova Zambo, Iva, Urban, Jiri, Macsek, Peter, Pazourek, Lukas, Tomas, Tomas, Veselska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305892/
https://www.ncbi.nlm.nih.gov/pubmed/34298757
http://dx.doi.org/10.3390/cancers13143543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305892/
https://www.ncbi.nlm.nih.gov/pubmed/34298757
http://dx.doi.org/10.3390/cancers13143543

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