A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe

In this study, we designed, synthesized and evaluated, in vitro, novel chalcone analogs containing dialkylamino pharmacophores in the cervical cancer cell line, OV2008. The compound, DML6 was selective and significantly decreased the proliferation of OV2008 and HeLa cells in sub-micromolar concentra...

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Detalles Bibliográficos
Autores principales: Len, Jenna M., Hussein, Noor, Malla, Saloni, Mcintosh, Kyle, Patidar, Rahul, Elangovan, Manivannan, Chandrabose, Karthikeyan, Moorthy, N. S. Hari Narayana, Pandey, Manoj, Raman, Dayanidhi, Trivedi, Piyush, Tiwari, Amit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306139/
https://www.ncbi.nlm.nih.gov/pubmed/34299490
http://dx.doi.org/10.3390/molecules26144214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306139/
https://www.ncbi.nlm.nih.gov/pubmed/34299490
http://dx.doi.org/10.3390/molecules26144214

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