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Focused Ion Microbeam Irradiation Induces Clustering of DNA Double-Strand Breaks in Heterochromatin Visualized by Nanoscale-Resolution Electron Microscopy

Background: Charged-particle radiotherapy is an emerging treatment modality for radioresistant tumors. The enhanced effectiveness of high-energy particles (such as heavy ions) has been related to the spatial clustering of DNA lesions due to highly localized energy deposition. Here, DNA damage patter...

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Detalles Bibliográficos
Autores principales:	Lorat, Yvonne, Reindl, Judith, Isermann, Anna, Rübe, Christian, Friedl, Anna A., Rübe, Claudia E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306362/ https://www.ncbi.nlm.nih.gov/pubmed/34299263 http://dx.doi.org/10.3390/ijms22147638

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