Cockayne Syndrome-Associated CSA and CSB Mutations Impair Ribosome Biogenesis, Ribosomal Protein Stability, and Global Protein Folding

Cockayne syndrome (CS) is a developmental disorder with symptoms that are typical for the aging body, including subcutaneous fat loss, alopecia, and cataracts. Here, we show that in the cells of CS patients, RNA polymerase I transcription and the processing of the pre-rRNA are disturbed, leading to...

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Detalles Bibliográficos
Autores principales: Qiang, Mingyue, Khalid, Fatima, Phan, Tamara, Ludwig, Christina, Scharffetter-Kochanek, Karin, Iben, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306422/
https://www.ncbi.nlm.nih.gov/pubmed/34203326
http://dx.doi.org/10.3390/cells10071616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306422/
https://www.ncbi.nlm.nih.gov/pubmed/34203326
http://dx.doi.org/10.3390/cells10071616

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