In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB

Human DNA topoisomerase IB controls the topological state of supercoiled DNA through a complex catalytic cycle that consists of cleavage and religation reactions, allowing the progression of fundamental DNA metabolism. The catalytic steps of human DNA topoisomerase IB were analyzed in the presence o...

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Detalles Bibliográficos
Autores principales: Soren, Bini Chhetri, Babu Dasari, Jagadish, Ottaviani, Alessio, Messina, Beatrice, Andreotti, Giada, Romeo, Alice, Iacovelli, Federico, Falconi, Mattia, Desideri, Alessandro, Fiorani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306514/
https://www.ncbi.nlm.nih.gov/pubmed/34299074
http://dx.doi.org/10.3390/ijms22147455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306514/
https://www.ncbi.nlm.nih.gov/pubmed/34299074
http://dx.doi.org/10.3390/ijms22147455

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