Potency- and Selectivity-Enhancing Mutations of Conotoxins for Nicotinic Acetylcholine Receptors Can Be Predicted Using Accurate Free-Energy Calculations

Nicotinic acetylcholine receptor (nAChR) subtypes are key drug targets, but it is challenging to pharmacologically differentiate between them because of their highly similar sequence identities. Furthermore, α-conotoxins (α-CTXs) are naturally selective and competitive antagonists for nAChRs and hol...

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Detalles Bibliográficos
Autores principales: Katz, Dana, DiMattia, Michael A., Sindhikara, Dan, Li, Hubert, Abraham, Nikita, Leffler, Abba E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306581/
https://www.ncbi.nlm.nih.gov/pubmed/34202022
http://dx.doi.org/10.3390/md19070367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306581/
https://www.ncbi.nlm.nih.gov/pubmed/34202022
http://dx.doi.org/10.3390/md19070367

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