Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels

Hypoxia is an important phenomenon in solid tumors that contributes to metastasis, tumor microenvironment (TME) deregulation, and resistance to therapies. The receptor tyrosine kinase AXL is an HIF target, but its roles during hypoxic stress leading to the TME deregulation are not well defined. We r...

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Detalles Bibliográficos
Autores principales: Goyette, Marie-Anne, Elkholi, Islam E., Apcher, Chloé, Kuasne, Hellen, Rothlin, Carla V., Muller, William J., Richard, Darren E., Park, Morag, Gratton, Jean-Philippe, Côté, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307381/
https://www.ncbi.nlm.nih.gov/pubmed/34266948
http://dx.doi.org/10.1073/pnas.2023868118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307381/
https://www.ncbi.nlm.nih.gov/pubmed/34266948
http://dx.doi.org/10.1073/pnas.2023868118

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