Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells

Hutchinson–Gilford progeria syndrome (HGPS) is an ultra-rare multisystem premature aging disorder that leads to early death (mean age of 14.7 years) due to myocardial infarction or stroke. Most cases have a de novo point mutation at position G608G within exon 11 of the LMNA gene. This mutation leads...

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Detalles Bibliográficos
Autores principales: Arnold, Rouven, Vehns, Elena, Randl, Hannah, Djabali, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307450/
https://www.ncbi.nlm.nih.gov/pubmed/34299092
http://dx.doi.org/10.3390/ijms22147474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307450/
https://www.ncbi.nlm.nih.gov/pubmed/34299092
http://dx.doi.org/10.3390/ijms22147474

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