Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a serious global public health threat. The 3C-like protease (3CLpro) is a virus protease encoded by SARS-CoV-2, which is essential for virus replication. We have previously reported a series of small-molecule 3CLp...

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Detalles Bibliográficos
Autores principales: Dampalla, Chamandi S., Zheng, Jian, Perera, Krishani Dinali, Wong, Lok-Yin Roy, Meyerholz, David K., Nguyen, Harry Nhat, Kashipathy, Maithri M., Battaile, Kevin P., Lovell, Scott, Kim, Yunjeong, Perlman, Stanley, Groutas, William C., Chang, Kyeong-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307543/
https://www.ncbi.nlm.nih.gov/pubmed/34210738
http://dx.doi.org/10.1073/pnas.2101555118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307543/
https://www.ncbi.nlm.nih.gov/pubmed/34210738
http://dx.doi.org/10.1073/pnas.2101555118

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