Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses

BRCA2 is an essential genome stability gene that has various functions in cells, including roles in homologous recombination, G2 checkpoint control, protection of stalled replication forks, and promotion of cellular resistance to numerous types of DNA damage. Heterozygous mutation of BRCA2 is associ...

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Detalles Bibliográficos
Autores principales: Andreassen, Paul R., Seo, Joonbae, Wiek, Constanze, Hanenberg, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307705/
https://www.ncbi.nlm.nih.gov/pubmed/34356050
http://dx.doi.org/10.3390/genes12071034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307705/
https://www.ncbi.nlm.nih.gov/pubmed/34356050
http://dx.doi.org/10.3390/genes12071034

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