Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations

The kinase insert domain (KID) of RTK KIT is the key recruitment region for downstream signalling proteins. KID, studied by molecular dynamics simulations as a cleaved polypeptide and as a native domain fused to KIT, showed intrinsic disorder represented by a set of heterogeneous conformations. The...

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Detalles Bibliográficos
Autores principales: Ledoux, Julie, Trouvé, Alain, Tchertanov, Luba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307779/
https://www.ncbi.nlm.nih.gov/pubmed/34298994
http://dx.doi.org/10.3390/ijms22147375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307779/
https://www.ncbi.nlm.nih.gov/pubmed/34298994
http://dx.doi.org/10.3390/ijms22147375

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